Authors: Arya Aminorroaya MD MPH, Lovedeep S Dhingra MBBS, Evangelos K Oikonomou MD DPhil, Rohan Khera MD MS

Disclosures: Dr. Khera is an Associate Editor at JAMA and receives research grant support, through Yale, from Bristol‐Myers Squibb and Novo Nordisk. He is a coinventor of U.S. Pending Patent Applications 63/177,117, 63/346,610, and 63/428,569, unrelated to the current work. He receives support from the Blavatnik Foundation through the Blavatnik Fund for Innovation at Yale. He is a co-founder of Evidence2Health, a precision health platform to improve evidence-based cardiovascular care. Dr. Oikonomou is a co-founder of Evidence2Health and reports a consultancy with Caristo Diagnostics Ltd (Oxford, U.K.), unrelated to the current work. The remaining authors have no disclosures to report.

Acknowledgments: The American Heart Association Precision Medicine Platform (https://precision.heart.org/) was used for data analysis. The datasets used for the analyses described were obtained from Vanderbilt University Medical Center’s BioVU which is supported by numerous sources: institutional funding, private agencies, and federal grants. These include the NIH funded Shared Instrumentation Grant S10RR025141; and CTSA grants UL1TR002243, UL1TR000445, and UL1RR024975.